Fariha Munir, Author at Spark Health MD

Mysterious Blood Clots Found Inside Coronavirus Patients

Today, there is a far-reaching fact that the novel coronavirus is a lot more serious than a basic respiratory infection. Frequently it assaults the lungs, yet it can also strike anywhere from the cerebrum to the toe. Numerous specialists are centered around treating the inflammatory reactions it triggers and its ability to cause mysterious blood clots, even as they battle to enable patients to breathe.

A new study done by the researchers at Brighton and Sussex Medical School (BSMS), UK finds that COVID-19 is related to a high frequency of venous thromboembolism, blood clots in the venous circulation. More than two hundred consecutive cases of coronavirus patients were admitted to the hospital and a critical percentage of 7.7 percent were diagnosed with venous thromboembolism.

A hematologist at Weill Cornell Medicine in New York City, Dr. Jeffrey Laurence says, “The number of clotting problems I’m seeing in the ICU [intensive care unit], all related to COVID-19, is unprecedented.”

The most common type of venous thromboembolism is pulmonary embolism, a blood clot on the lungs that was seen in more than 75 percent of these coronavirus patients. The researchers found that that the D-dimer blood test was helpful to distinguish those patients at the most noteworthy risk of venous thromboembolism when admitted to the hospital.

Venous thromboembolism (VTE) is also known as blood clots. This is underdiagnosed and serious, however, it can be prevented. It is essential to know about Venous thromboembolism (VTE) because it can transpire at any age and cause severe illness, disability, and even death in a few cases. Fortunately, it can be prevented and treated whenever found early.

Study in detail here.

A cardiac specialist at the Yale-New Haven Hospital Center, Harlan Krumholz says that one of the speculations is that once the body is so occupied with a battle against an invader, the body begins consuming the clotting factors, which can result in either blood clots or bleeding. “In Ebola, the balance was more toward bleeding. In COVID-19, it’s more blood clots.”

Purple rashes, clogged catheters, swollen legs, sudden death, and formation of mysterious blood clots inside coronavirus patients are a frequent complication of COVID-19, and analysts are simply starting to unwind why. For quite a long time, reports have poured in of the disease’s effects all through the body, a significant number of which are brought about by blood clots.

Some doctors noticed that most of their coronavirus patients were developing blood clots in the legs, even while they all were on blood thinners.

A fourth-year cardiology fellow at Columbia University in New York City, Behnood Bikdeli says, “This is like a storm of blood clots.” Anybody with a serious disease is at risk of developing mysterious blood clots, however, hospitalized patients with COVID-19 appear to be more susceptible.

Dr. Chi Eziefula is the lead author of the study and a Senior Lecturer in Infection at BSMS. In this study, she says that it is highly important to know which patients are at risk of venous thromboembolism because it is treatable with anticoagulant drugs and linked to the risk of death.

A Reader in Haematology at BSMS, Dr. Tim Chevassut says that the present study signals the significance of further research to investigate the pathological mechanisms that are specific to COVID-19. It additionally highlights the dire requirement for clinical trials to assess the role of anticoagulation treatment for the counteraction of morbidity and death from COVID-19 infection

Study Finds a New Non-Invasive Diagnostic Test for Endometrial Cancer

Researchers have found a new non-invasive diagnostic test for endometrial cancer. This test helps in the early detection of endometrial cancer and in patients who are at risk.

This study is done by the researchers at the University of Central Lancashire (UCLan), University of Manchester, and the Federal University of Rio Grande do Norte, in collaboration with clinicians from NHS Trusts across Manchester, Lancashire and London and published in the journal Cancers.

This study provides a cheap diagnostic test for endometrial cancer and its common precursor, atypical hyperplasia. When researchers used this diagnostic test in the clinical setting, they came to know that this test can create instantaneous outcomes for women who are at risk of developing signs of endometrial cancer.

In this study, blood samples of more than six hundred women were analyzed by using blood spectroscopy, a technique in which light is used to decide the molecular makeup of a sample. While doing this, the researchers produced a biological fingerprint that was indicative of specific lipids, proteins, and biomolecules that helped to diagnose the patients with endometrial cancer or its precursor atypical hyperplasia.

The researchers found that this diagnostic test for endometrial cancer has 83 percent accuracy to detect patients with endometrial cancer. Type 1 endometrial cancer is the most common subtype and the accuracy of this diagnostic test is highest for the type I endometrial cancer. While the accuracy of this test for atypical hyperplasia is 90 percent. This is a precancerous condition in which the endometrial tissue is affected and often leads to cancer.

Endometrial cancer is right now the 6th most common disease in women, with rising occurrence over the world. Current methodologies for the screening and diagnosis of endometrial cancer are intrusive, costly, or of moderate symptomatic exactness, which can confine their clinical utility.

Four years before, the NHS set out the ambitious objective that diagnosis ought to be established within four weeks of going to essential consideration. The present study confirms the potential clinical use of non-invasive diagnostic test strategy which could assist with arriving at this objective and in identifying endometrial cancer early.

At the point when applied in a clinical setting, this test could likewise assist with mitigating pressure on auxiliary mind and guarantee that just those at noteworthy risk of disease are recognized and alluded for further invasive diagnostic testing.

Dr. Maria Paraskevaidi is the lead investigator of the study and research associate at the University of Central Lancashire (UCLan) and Imperial College London. In this study, she says that regardless of the rising occurrence of endometrial cancer all through the world, there have been not many advances made in improving the analysis and prognosis of endometrial cancer.

This research flags a significant advance forward for patients. The research community and clinicians have the potential to be developed into a low-cost, simple, and immediate diagnostic test for endometrial cancer in the future.

A Research Director at Lancashire Teaching Hospital and a consultant in gynecological cancer surgery, Dr. Pierre Martin-Hirsch tells that this is a potential distinct advantage in the early diagnose of endometrial cancer. She is glad for the accomplishments of this collaborative team.

Emma Crosbie is a professor in gynecological oncology at the University of Manchester. She says that this research is an exciting advancement in diagnosing endometrial cancer. Current diagnostic tests depend upon personal and expensive labor-intensive techniques with moderate accuracy that are terrible for women, so researchers are amped up for the possibility of this test being utilized to improve early diagnosis and quick track women for treatment.

Coronavirus Pandemic Could Cause Childhood Obesity

The nutritionists around the globe are worried that the closing of schools, play areas, sports fields, and summer camps due to coronavirus pandemic could prompt a future spike in childhood obesity due to changes in eating routines and habits and a decrease in physical activities.

A report from the Centers for Disease Control and Prevention (CDC) indicates that childhood obesity has been increasing since the previous four decades in the whole world.

Rima Himelstein is a pediatrician specializing in adolescent health at Nemours/Alfred I. DuPont Hospital for Children in Wilmington. She says, “With quarantine, it’s basically like an extended summer.” Children don’t have the opportunity to work out and take an interest in physical exercises like they take normally in their summer holidays.

The sedentary idea of online classes is also troubling. Children do not stroll from one room to another for their classes or have planned outside time and gym class. Also, numerous guardians are overloading their pantries with increasingly prepared foods that have longer periods of usability to limit the number of market trips, which can lead to overeating foods that frequently have high sugar and sodium levels.

More than 33 percent of youth under age nineteen are obese or overweight. Childhood obesity is characterized as a body mass index (BMI) or over the 95th percentile for adolescents of a similar age and sex, which implies their BMI is higher than that of 95% of their friends.

Angela Luciani is a registered dietitian in Philadelphia, She says that kids, particularly those who are already obese or from minority groups gain weight at a quicker rate during their summer vacations as compared to their school year. Researchers think that this happens largely because the food that children eat at home might be less nutritious than the food they eat at school.

The director of family medicine at the Philadelphia College of Osteopathic Medicine, Peter Bidey is concerned for children because they spend their most of time in front of screens. During this coronavirus pandemic, people are stuck in their homes. They are doing nothing. He said families might be eating more comfort foods which may high in calories and have no nutritional value as in fresh foods.

Bidey says that parents can protect their kids from childhood obesity during coronavirus pandemic by giving them healthy and fresh food.

Luciani suggests that guardians should ensure there are healthy snacks in the house. They should set times for breaks on the whole day for their kids.

She said, “Families should make physical activity intentional. They should implement it as a daily part of their routine, like taking a 20-minute walk at lunchtime, going for a bike ride, or trying fitness apps and workouts on YouTube if it’s raining out. Even TikTok is a great way for people to get up and dance.”

The American Academy of Pediatrics recommends an exercise of an hour per day for teenagers. But it can be started with ten minutes and afterward parents should reward their kids for the progress they will make.

Himelstein also recommends eating healthy and fresh food and to adopt healthy activities like exercise, yoga, etc for feeling better not for looking great. She called attention that praising kids for losing weight could prompt an elusive incline. Instead, activities ought to be fun and loaded up with variety, “to animate various pieces of the cerebrum by moving in various ways.”

She advises people to use stairs, vegetables, and fruits at home. People should record their activities in a diary so that they can see everything they’re doing now contrasted with what they weren’t doing previously.

More than 90% of Australians Cannot Differentiate Between a Viral and Bacterial infection (Report)

The whole world is facing a global viral outbreak for the last five months and till the date, there are more than 250000 COVID-19 cases reported. Public health awareness matters whether or not there is a medical threat around; but what’s the reason that more than 90 percent of Australians can’t even differentiate between a viral and bacterial infection?

Dr. Paul De Barro is a Senior Principal Research Scientist and is the Research Director of the CSIRO Health & Biosecurity’s Risk Evaluation and Preparedness Program. He says that CSIRO carried a survey two months before to let everyone know their work on the OUTBREAK project, a multi-agency mission aimed at preventing outbreaks of antibiotic-resistant bacterial infections.

The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is an Australian federal government agency responsible for scientific research. This organization works with leading organizations around the globe.

CSIRO reports that more than two thousand individuals highlight a lack of knowledge about viral and bacterial infections. It informs that 13 percent of Australians wrongly trust that a viral disease, COVID-19 can be treated by using antibiotics that treat bacterial infections.

More than 33 percent of respondents thought that antibiotics would fix their seasonal influenza or an irritated throat while 15 percent thought antibiotics were effective against diarrhea or chickenpox. While antibiotics are medications that destroy the growth of bacteria.

While 25 percent of them were unaware of antibiotic resistance and 14 percent conceded that antibiotics didn’t treat an infection.

The outcomes are deeply stressing because individuals who don’t know how antibiotics work or for which purpose antibiotics are taken are more likely to overuse or misuses them. This thusly fills the ascent of drug resistance bacteria also called “superbugs” and risky infections.

While COVID-19 has pushed the economy to the edge of total collapse, superbugs pose financial difficulties as well. Australian medical clinics have already spent more than A$11 million a year treating only two of the most compromising, drug resistance infections, methicillin-resistant MRSA and ceftriaxone-resistant E. coli.

People will die from sepsis because of the unavailability of effective antibiotics, and the people will sicker for longer, reducing the size of profitability and workforce. The drug-resistant bacteria are figure to cost the country at least A$283 billion and more deaths than cancer by 2025.

One pivotal approach to stop this is to improve public knowledge of the value of antibiotics. It is hard to replace the antibiotics that lose their adequacy so they should be treated with deference.

They don’t know the full effect of drug-resistant bacteria in Australia. With about 75 percent of rising infectious diseases originating from animals, there is no time to squander in getting a better understanding of superbugs among people, animals, and the earth. That is the place the OUTBREAK project comes in.

The University of Technology Sydney analyzes an enormous measure of human, environmental, and animal data by using artificial intelligence, making a nationwide system that can anticipate antibiotic-resistant infections in actual time. It maps and models reactions and gives significant data to specialists, committees, ranchers, vets, water authorities, and other stakeholders.

OUTBREAK offers Australia a chance to jump on the front foot against drug-resistance bacteria. This opportunity to Australia will help to save a huge number of lives and billions of dollars could even be scaled worldwide.

They suggest Australians not to use antibiotics unnecessarily. Australians need to know the difference between viral and bacterial infections. Without antibiotics, people may end up confronting a large group of new severe diseases, even as the world is facing COVID-19.

The U.S is Ready to Invest $5 trillion to Get Rid of Coronavirus

A new report suggests that Americans are ready to pay about US$5 trillion to get rid of coronavirus and save many lives as the U.S now leads the world in confirmed COVID-19 cases. The Treasury Department will borrow about $3 trillion in the following three months. That is practically triple what the Treasury acquired for the entirety of 2019. Congress has so far consented to spend $3 trillion to help the U.S economy and its workers.

They concluded that an average person is ready to pay $15,000 to decrease the number of cases through shelter-in-place, social distancing, and different mediations.

Centers for Disease Control and Preventions (CDC) reports that The National Ensemble Forecast suggests that the number of deaths will exceed 0.1 million in the United States by June 1st. It also indicates that the countries in which a high number of deaths are reported are most likely to see a rise in the coronavirus cases in the coming weeks while countries with less number of deaths will experience less number of cases.

Health authorities say that strong social distancing measures should not be removed while others want that the restrictions lifted right away. Economists frequently compute what individuals are happy to pay to find a response to questions like these.

It would not be sensible to hold back to facilitate the limitations until the casualty pace of COVID-19 tumbles to zero. They accept deaths emerging from the seasonal flu and deaths that could be avoided by providing more facilities for medical research.

More than 1.44 million people are infected with the virus in the United States, and the number of deaths is more than eighty thousand. It’s their failure that they didn’t take coronavirus pandemic seriously even as it emerged in China. They failed to provide broad testing for the disease and left the nation heedless to the extent of the crisis. The people in the country faced a shortage of masks, ventilators, and protective gear for the protection of their doctors and nurses.

The director of the Center on US-China Relations at the Asia Society, Orville Schell says, “We’re essentially in the beginnings of a Cold War. We are on a downward slide into something increasingly adversarial with China.”

This research shows that, in the total, the advantages in terms of lives spared and morbidity avoided can well legitimize the gigantic economic cost brought by social distancing measures.

An important warning, however, is that since the greater part of the advantages of these measures gather to a relatively little group of profoundly helpless people, while the cost trouble falls on the whole populace, not every person may eagerly acknowledge those measures, as confirm by protests against the lockdowns.

The outcomes of this research are suggestive. Some of the assumptions of this research in regards to the spread of infection, the risk factors associated with the severe disease, how emergency clinics respond to surge like coronavirus pandemic may refute. Furthermore, much experimental investigation stays to be done, particularly according to the nonmonetary advantages and expenses of social distancing intercessions. Researchers are trying hard to get rid of coronavirus.

The researchers have shown a lot of interest in coronavirus pandemic. The European Economic Association alone records more than two hundred projects investigating information related with the coronavirus pandemic, going from attempting to comprehend the macroeconomic outcomes to assessing the viability of social distancing intercessions.

The New Re-purposed Drug Proven Effective for Weight Loss in Lab Trials

A new study from the journal Cell Metabolism finds that disulfiram, a drug that previously used for the treatment of alcohol use disorders is effective for weight loss and switch metabolic damage in obese middle-aged mice of both sexes. This study is done by the researchers at the National Institute on Aging (NIA) that is a part of the National Institutes of Health.

Researchers studied nine-month-old lab mice who fed a high-fat diet for 84 days. This eating of high fat made the mice overweight and they began to show signs of pre-diabetes-like metabolic issues like insulin resistance and increased fasting glucose levels.

Researchers divided them into four groups and each group received a different diet for eighty-four days: a high-fat diet, a high-fat diet with a low amount of re-purposed drug disulfiram, a standard eating routine alone, and a high-fat diet alone.

The mice group fed with a high-fat diet alone gained weight and show metabolic problems. While weight loss was seen in the group fed with standard diet alone, their glucose levels and body fat returned to normal.

Michel Bernier, the NIA scientists, and Rafael de collaborate frequently with researchers at NIH and into how changes in dietary patterns such as intermittent fasting could physical and health advantages. They first got inspired by disulfiram in the wake of finding out about the advantages that this class of medication has appeared in treating type 2 diabetes in rats, coupled with the growing interest for re-purposing drugs that may improve healthy aging too.

A dramatic weight loss was observed in the mice who were fed with a low or high dose of re-purposed drug disulfiram. Mice on the high disulfiram dose lost as much as 40% of their body weight in only a month, adequately normalizing their weight to that of obese mice who were exchanged back to the standard diet.

Mice in the disulfiram dose diet group became less fatty and demonstrated noteworthy improvement in blood glucose levels compared to the mice who were returned to the standard diet. Disulfiram treatment also seemed to shield the pancreas and liver from damage brought about by pre-diabetic type metabolic changes and body weight usually increases due to eating a high-fat diet.

Bernier tells that when they started working on this, they didn’t have the idea but once they began to see data indicating dramatic weight loss, they couldn’t even believe their eyes after seeing outcomes.

The researchers say that the positive outcomes were appeared due to the anti-inflammatory properties of re-purposed drug disulfiram that prevented mice from the damage of fatty diet and gaining weight.

In both groups of mice neither any spontaneous behavioral changes were demonstrated nor they were subjected to any type of exercise. The outcomes show that disulfiram was effective to them and not any negative side effects were seen in them from disulfiram.

The present study was supported by NIA through its intramural research program, NIA grants AG038072 and AG031782 in collaboration with colleagues from the National Institute of Alcohol Abuse and Alcoholism, Yale University, Albert Einstein College of Medicine, Korea Research Institute of Bioscience and Biotechnology, and University of Sydney, Australia.

The research team stresses that the present study outcomes depend upon animal studies they can’t be extrapolated to any potential advantages for humans now. Researchers are still planning future strides for considering disulfiram’s potential, including a controlled clinical examination to test if it could assist people with morbid obesity lose weight.

Coronavirus and Child Abuse (John Hopkins University Report)

Ever since the coronavirus lockdown was imposed in multiple countries, the workers at the National Sexual Assault Hotline have made a new shocking revealing. As to them, this is the first time ever that half of the hotline calls were made by children younger than 18. These callers discussed their worries about their safety while disengaged at home during the coronavirus pandemic.

The inaugural director of the Moore Center for the Prevention of Child Sexual Abuse, Elizabeth Letourneau says that the coronavirus emergency has incidentally produced two areas of concern. First, they accept that the risk for online offending has increased because children spent most of the time online for education and recreation. Second, they also accept that risk offending perpetrated by family members has increased because children and adults do not spend much time together.

Letourneau is a professor in the Department of Mental Health at the Bloomberg School and she has spent more than twenty years researching and evaluating legal policy.

Recently, The Moore Center assembled several resources for families to prevent child sexual abuse during the lockdown and for people worried about their own sexual emotions including children. The Centre additionally optimized the release of a free online course called Help Wanted that helps individuals who are pulled to children practice healthy.

Letourneau says that they want to help parents a little bit of support as they explore the entirety of this increased online behavior and behavior between children and adults at home.

The issue of child sexual abuse is perplexing, and social distancing may intensify a few risks for minors while alleviating others. As most instances of child sexual abuse occur outside of the setting of the family, so-called extrafamilial offenses perpetrated by people who are not family members. It is expected that rates of extrafamilial offenses will drop under social distancing rules.

Letourneau suggests that these risks can be confronted if parents have open and frank discussions with their children about appropriate and wrong online behaviors and interactions. Through these discussions, guardians may turn out to be more aware of risky behaviors or wrong connections including their children.

In the midst of these increased risks, associations committed to preventing child sexual abuse like Stop It Now! have revealed increased traffic to their site pages for individuals who are worried about their sexual musings and behaviors.

Letourneau and her co-investigator, Michael Seto from the Royal Ottawa Healthcare Group decided to make a resource page for individuals who may be at risk of offending. Letourneau and her Moore Center partners chose to debut their Help Wanted prevention course early.

Letourneau says, “The stigma associated with having a sexual interest in children is tremendous, but having the attraction does not doom a person to acting on that attraction. Many people make the decision to keep children safe and to keep themselves safe by not acting on it. They need support.”

The Help Wanted course is intended for individuals who self-recognized as having sexual interest for kids and who are searching for help managing those emotions, stigma, or different concerns. It contains five meetings that can be accessed anonymously and in any request.

The meetings are focus on issues like understanding sexual abuse, developing healthy sexual behaviors, coping with an attraction to children, and leading nonoffending lives.

Letourneau says that inadequate resources go to supporting survivors, and there’s not almost a sufficient spotlight on avoidance. Some portion of their main goal is to enable general society to comprehend that child sexual abuse is a preventable general health issue. There is nothing inescapable about it.

Zinc Might Improve the Treatment of COVID-19 patients

The antimalarial drug, hydroxychloroquine has been previously announced as a ‘game-changer’ in treating COVID-19 patients. But the recent studies show contrasting outcomes have been seen in COVID-19 patients. Some patients claim that this drug improved their condition while others blame that it brings cure for the adverse reactions.

Since U.S. President Donald Trump upheld the medication hydroxychloroquine as a potential treatment for COVID-19 patients, numerous lupus patients have attempted to get the medication while many of them state they can’t live without.

President Donald Trump called chloroquine and hydroxychloroquine a “game-changer.” He said, “I feel good about it.” But most of the doctors are not so sure about its effectiveness against COVID-19.

Philip M. Carlucci is from New York University Grossman School of Medicine in New York City, he and his colleagues collected data from electronic medical records for COVID-19 patients. Hospital outcomes were analyzed for more than four hundred patients who received azithromycin and hydroxychloroquine versus more than five hundred patients who received azithromycin and hydroxychloroquine alone.

The CDC reports that no drug or vaccine is approved by the U.S. Food and Drug Administration (FDA) to treat COVID-19 patients. The National Institutes of Health (NIH) have published guidelines for medical management of COVID-19 that will update all therapeutic interventions that are approved for use by the Food and Drug Administration (FDA).

The analysts found that the zinc sulfate addition did not change the length of hospitalization, duration of ventilation, or span of intensive care unit ( ICU). Zinc sulfate increased the frequency of patients being discharged home and decreased the requirement for ventilation, admission to the intensive care unit (ICU), and mortality or move to hospice for patients not admitted to the intensive care unit (ICU) in univariate analyses.

Zinc itself has antiviral properties. Past investigations have suggested that it could lessen the time individuals experience from the common cold. Joseph Rahimian is an infectious disease specialist. He says that the effectiveness of zinc increases when combined with hydroxychloroquine in treating COVID-19 patients. He includes that it could be the essential component assaulting the infection and hydroxychloroquine could serve as an agent that transport the zinc into the cells.

The Food and Drug Administration issued a warning that the drugs chloroquine and hydroxychloroquine that are repeatedly promoted by President Donald Trump should be used only for clinical trials. These drugs can cause risky variation in heart rhythm in COVID-19 patients, and ought to be used distinctly in clinical trials or emergency clinics where patients can be closely observed for heart issues.

Many medical societies including the American Thoracic Society, the American College of Cardiology, and the Infectious Diseases Society of America have warned risks of using these drugs to treat COVID-19 patients outside of a clinical trial or without close monitoring.

Many doctors are using hydroxychloroquine for the treatment of Covid-19, the disease caused by coronavirus because no vaccine or any other effective treatment is available against it.

The FDA statement said,

“The F.D.A. is aware of reports of serious heart rhythm problems in patients with Covid-19 treated with hydroxychloroquine or chloroquine, often in combination with azithromycin”

So findings remained significant for more frequency of being discharged and decrease in mortality or move to hospice after modification for the time at which zinc sulfate was added to the convention.

The authors say that the present study should not be used to control clinical practice. Their perceptions support the inception of future randomized clinical trials exploring zinc sulfate against COVID-19 patients.

Eating High Saturated Fat Food Reduces Work Performance

A new study published in the American Journal of Clinical Nutrition suggests that eating high saturated food can reduce the capacity to work. This is not good news for those who are working from home during the COVID-19 pandemic as fatty food may feel like a companion during these grieved occasions.

The researchers performed a test on fifty-one women to check their work performance after eating high saturated fat food and high unsaturated fat food. The work performance was worse after eating high saturated fat food than after eating high unsaturated fat food.

They were also looking to find any effect of a condition called leaky gut which permits intestinal microscopic organisms to enter the circulatory system. Participants with leakier guts performed worse on the work performance regardless of which food they had eaten.

Annelise Madison is the lead author of the study and a graduate student in clinical psychology at The Ohio State University. In this study, she noticed that the meal made with sunflower oil that is low in saturated fat still contained a great deal of dietary fat.

Because both meals, high in saturated fat and low in saturated fat were potentially risky. The high saturated fat food cognitive impact could be considerably more prominent if it were compared with a low saturated fat food.

Annelise Madison works in the lab of Janice Kiecolt-Glaser who is a professor of psychiatry and psychology and director of the Institute for Behavioral Medicine Research at Ohio State. Madison also conducted a secondary analysis of the data from the study of Kiecolt-Glaser to know whether high saturated fat foods increase the risk of inflammation and fatigue in cancer survivors.

After eating high saturated fat food, eleven percent of women were less able to identify the target stimuli in the consideration assessment. Concentration lapses were also seeming in the participants with signs of leaky gut. Their reaction times were more erratic and they were less ready to continue their attention during the 10-minute test.

The high saturated fat foods included biscuits, eggs, turkey sausages, and gravy that contains sixty gram of fat either lower-saturated-fat sunflower oil or a palmitic acid-based oil high in saturated fat.

Madison tells that presence of high levels of endotoxemia affected their work performance regardless of what sort of food they ate.

Although the study didn’t figure out what was happening in the brain, Madison says that past studies have proposed that high saturated fat food can drive up inflammation all through the body, and the brain. Unsaturated fats can cross the blood-brain obstruction too.

She says, “It could be that fatty acids are interacting with the brain directly. What it does show is the power of gut-related dysregulation. “

Kiecolt-Glaser tells that the present study suggests that concentration could be considerably more impaired in the individuals worried by the pandemic, who are turning to high saturated fat foods for comfort and they are not aware that food rich in fats can affect their work performance.

She said that what they know is that when individuals are stressed or more anxious, a great subset of them will find high saturated fat food more tempting than broccoli. They came to know from another study that anxiety and depression can interfere with attention and concentration too. At the point when they included that top of the high saturated fat food, they could expect the real-world impacts to be significantly larger.

How Human Body Naturally Heals the Emotional Pain?

A new study published in the journal the Nature Chemical Biology finds that the endogenous compound anandamide performs a role in erasing reminiscences of the traumatic event and it naturally modulates the emotional pain. This study is done by an international team led by Leiden chemist Mario van der Stelt, might be a starting point for the treatment of anxiety disorders like PTSD.

The research started five years before when the first author of the study, Elliot Mock and Anouk van der Gracht figured out how to isolate the protein NAPE-PLD that is responsible for the production of anandamide in the brain. The subsequent step was to locate a compound that prevents this protein from working, the thought was that repressing the production of anandamide would permit them to study the biological role of anandamide.

Seeing such a substance turned out as no mean accomplishment. Van der Stelt went to the European Lead Factory in Oss, the Netherlands, which was co-founded by his examination group seven years before and had practical experience in the quick screening of a huge number of substances. He originally needed to make sure about EU approval before a completely automated system could begin scanning for the compound that represses the protein.

When individuals feel emotional pain, the similar areas of the brain get activated as the anterior cingulate cortex and the anterior insula gets activated when individuals feel physical pain. A study shows that these regions were activated when individuals encountered social rejection from peers. While in 2011 study the same regions were activated when individuals’ relationship with their romantic partners was broken.

Van der Stelt said that this included more than 0.3 million mini reactions each with an alternate substance. It took only three days to screen these substances that seem very impressive.

At the end of the screening, the researchers developed a promising molecule that blocks the anandamide’s production but Van der Stelt tells that this molecule wasn’t ready at that point. So Elliot started working on it. Mock optimized it, and along with various students, went through two years synthesizing more than a hundred analogs, molecules that vary slightly from one another. One of these, in the end, revealed the role of anandamide in the body.

All feelings have a motor component. Regardless of whether a person attempts to hide emotions, there will be muscular activation. The foremost cingulate is located right next to the premotor area, which starts the process of emotional expression formation in the body. The premotor area associates with the motor cortex above it, and afterward back to the particular muscles of expression.

Van der Stelt tells that they began working with Roche Pharmaceuticals to analyze whether the brain received this optimized molecule, an essential condition. Roche confirmed that it reached the brain, the researchers named it LEI-401. Next, they started working with the researchers from the National Institutes of Health (NIH) in the United States to investigate whether this substance truly works in the brain. “That also turned out to be the case.”

Following three years, the way was at last open to answer the burning question about the physiological role of anandamide. This time, Van der Stelt approach partners in the United States and Canada to research the physiological impacts of reduced anandamide levels in the cerebrum. The researchers found that anandamide is involved in healing emotional pain; anxiety and stress.

Van der Stelt’s exploration opens the route for new strategies to treat anxiety disorders like PTSD. It is the beginning stage for the advancement of new drugs. As they have now indicated that anandamide is responsible for relieving emotional pain, pharmaceutical organizations can concentrate on a new target.