New research based at the Ohio University suggests that a certain subclass of the LDL or Low-Density Lipoproteins, also termed as the bad cholesterols can be a way better predictor for any potential chances of heart attacks as opposed to simple LDL presence.
The LDL presence is mostly considered as an indicator of any potential for heart attack-based risks or the possibility of coronary disease. However, studies note that 75% of the patients that suffer from heart issues have had cholesterol levels with no indication of high risks. This research conducted by Ohio University’s Professor Dr. Tadeusz Malinski & Dr. Jiangzhou Hua from Ohio University noted that 3 subclasses that make up the LDL, a mere one variant can cause a significant amount of damage.
Malinski also added that the study explains why there is a correlation between the heart risks associated and LDLs, which is incorrect most of the time. The national guidelines set for calculation of risk instances might seriously underestimate all the noxious effects seen from LDL cholesterol. This is especially true in cases where the content of the second subclass from total LDL tends to be high.
The team of researchers involved in the study used nanosensors for measurement of the nitric oxide concentration & peroxynitrite concentration in the endothelium is actually stimulated by the LDL subclasses. The findings of this study were reported and published over the latest of the International Journal of nanomedicine. The LDL belonging to the subclass B was noted to be among the highly damaging ones with regards to the endothelial functioning. With time, when left unchecked, it can further contribute to accelerated development of the heart health deteriorating disease called atherosclerosis. This is why it can safely be said that the total LDL cholesterol level found in one’s body has nothing to do with how they are diagnosed with heart issues. It is the subclass that should be considered the prime culprit behind such instances. Locating such critical factors can help provide a proper diagnosis for health issues in the future. If someone is running a risk of suffering from a heart attack, he/she should be checked for the lower LDLs to confirm the same.
Malinski also added that understanding this can help with improved accuracy with regards to the evaluation of the cardiovascular issues and instances of deaths related to the same. Analyzing the LDL subclasses can help set the right parameter for early diagnosis of the medical issue.