Study Finds a New Non-Invasive Diagnostic Test for Endometrial Cancer

Researchers have found a new non-invasive diagnostic test for endometrial cancer. This test helps in the early detection of endometrial cancer and in patients who are at risk.

This study is done by the researchers at the University of Central Lancashire (UCLan), University of Manchester, and the Federal University of Rio Grande do Norte, in collaboration with clinicians from NHS Trusts across Manchester, Lancashire and London and published in the journal Cancers.

This study provides a cheap diagnostic test for endometrial cancer and its common precursor, atypical hyperplasia. When researchers used this diagnostic test in the clinical setting, they came to know that this test can create instantaneous outcomes for women who are at risk of developing signs of endometrial cancer. 

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In this study, blood samples of more than six hundred women were analyzed by using blood spectroscopy, a technique in which light is used to decide the molecular makeup of a sample. While doing this, the researchers produced a biological fingerprint that was indicative of specific lipids, proteins, and biomolecules that helped to diagnose the patients with endometrial cancer or its precursor atypical hyperplasia.

The researchers found that this diagnostic test for endometrial cancer has 83 percent accuracy to detect patients with endometrial cancer. Type 1 endometrial cancer is the most common subtype and the accuracy of this diagnostic test is highest for the type I endometrial cancer. While the accuracy of this test for atypical hyperplasia is 90 percent. This is a precancerous condition in which the endometrial tissue is affected and often leads to cancer.

Endometrial cancer is right now the 6th most common disease in women, with rising occurrence over the world. Current methodologies for the screening and diagnosis of endometrial cancer are intrusive, costly, or of moderate symptomatic exactness, which can confine their clinical utility.

Four years before, the NHS set out the ambitious objective that diagnosis ought to be established within four weeks of going to essential consideration. The present study confirms the potential clinical use of non-invasive diagnostic test strategy which could assist with arriving at this objective and in identifying endometrial cancer early.

At the point when applied in a clinical setting, this test could likewise assist with mitigating pressure on auxiliary mind and guarantee that just those at noteworthy risk of disease are recognized and alluded for further invasive diagnostic testing.

Dr. Maria Paraskevaidi is the lead investigator of the study and research associate at the University of Central Lancashire (UCLan) and Imperial College London. In this study, she says that regardless of the rising occurrence of endometrial cancer all through the world, there have been not many advances made in improving the analysis and prognosis of endometrial cancer.

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This research flags a significant advance forward for patients. The research community and clinicians have the potential to be developed into a low-cost, simple, and immediate diagnostic test for endometrial cancer in the future.

A Research Director at Lancashire Teaching Hospital and a consultant in gynecological cancer surgery, Dr. Pierre Martin-Hirsch tells that this is a potential distinct advantage in the early diagnose of endometrial cancer. She is glad for the accomplishments of this collaborative team.

Emma Crosbie is a professor in gynecological oncology at the University of Manchester. She says that this research is an exciting advancement in diagnosing endometrial cancer. Current diagnostic tests depend upon personal and expensive labor-intensive techniques with moderate accuracy that are terrible for women, so researchers are amped up for the possibility of this test being utilized to improve early diagnosis and quick track women for treatment.